Zhang Heng, Sun Yifang, Li Kun, Zhang Jianzhong, Chen Xue
Department of Dermatology, Peking University People's Hospital, Beijing, 100044, People's Republic of China.
Clin Cosmet Investig Dermatol. 2022 Aug 9;15:1593-1596. doi: 10.2147/CCID.S374973. eCollection 2022.
Pyoderma gangrenosum (PG) is an inflammatory dermatosis characterized by the rapid progression of a painful, necrolytic ulcer with an irregular and undermined border. The prevalence of PG in patients with Crohn's disease (CD) has been estimated to be 0.7%. Here, we report a case that presented various painful skin lesions, including erythema, vesicles, plaques, and ulcers, one week before the fourth infliximab infusion for CD. PG was diagnosed and the lesions subsided after a 390-mg ustekinumab infusion for one month. It suggests that different lesions of PG may occur concomitantly in CD patients, and the therapy should be re-evaluated on time.
坏疽性脓皮病（PG）是一种炎症性皮肤病，其特征为疼痛性、坏死性溃疡迅速进展，边界不规则且呈潜行性。据估计，克罗恩病（CD）患者中PG的患病率为0.7%。在此，我们报告1例CD患者，在第4次英夫利昔单抗输注前1周出现各种疼痛性皮肤损害，包括红斑、水疱、斑块和溃疡。诊断为PG，在输注390 mg优特克单抗1个月后皮损消退。这表明PG的不同损害可能在CD患者中同时出现，且应对治疗及时重新评估。
