Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Department of Psychiatry, Department of Anatomy and Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Int J Methods Psychiatr Res. 2023 Mar;32(1):e1931. doi: 10.1002/mpr.1931. Epub 2022 Aug 15.
We describe the harmonized MRI acquisition and quality assessment of an ongoing global OCD study, with the aim to translate representative, well-powered neuroimaging findings in neuropsychiatric research to worldwide populations.
We report on T1-weighted structural MRI, resting-state functional MRI, and multi-shell diffusion-weighted imaging of 140 healthy participants (28 per site), two traveling controls, and regular phantom scans.
Human image quality measures (IQMs) and outcome measures showed smaller within-site variation than between-site variation. Outcome measures were less variable than IQMs, especially for the traveling controls. Phantom IQMs were stable regarding geometry, SNR, and mean diffusivity, while fMRI fluctuation was more variable between sites.
Variation in IQMs persists, even for an a priori harmonized data acquisition protocol, but after pre-processing they have less of an impact on the outcome measures. Continuous monitoring IQMs per site is valuable to detect potential artifacts and outliers. The inclusion of both cases and healthy participants at each site remains mandatory.
我们描述了正在进行的全球强迫症研究中协调一致的 MRI 采集和质量评估，旨在将神经影像学研究中的有代表性、有力的发现转化为全球人群。
我们报告了 140 名健康参与者（每个地点 28 名）、2 名流动对照者和常规体模扫描的 T1 加权结构 MRI、静息状态功能 MRI 和多壳扩散加权成像。
人体图像质量指标（IQMs）和结果测量值的场内变异性小于场间变异性。结果测量值的变异性小于 IQMs，尤其是对于流动对照者。体模 IQMs 在几何形状、SNR 和平均扩散率方面稳定，而 fMRI 波动在各站点之间变化更大。
即使对于预先协调的数据采集方案，IQMs 的变化仍然存在，但在预处理后，它们对结果测量值的影响较小。每个站点持续监测 IQMs 具有发现潜在伪影和异常值的价值。每个站点仍然必须包括病例和健康参与者。
