Echeverria P, Blacklow N R, Vollet J L, Ulyangco C V, Cukor G, Soriano V B, DuPont H L, Cross J H, Orskov F, Orskov I
J Infect Dis. 1978 Sep;138(3):326-32. doi: 10.1093/infdis/138.3.326.
Of 82 children hospitalized with diarrhea in the Philippines during January-June 1976, 14 (17%) had infections due to a reovirus-like agent as determined by detection of viral particles in stools by electron microscopy (12 [15%] of 82) and/or by a rise in titer of antibody to the serologically related Nebraska calf diarrhea virus (eight [20%] of 39). Escherichia coli producing heat-labile enterotoxin were found in six (7%) of 82 ill children and two (4%) of 49 healthy control children, while E. coli producing heat-stable enterotoxin were isolated from three children with diarrhea and two without gastroenteritis. Thirty-eight percent of enterotoxigenic E. coli isolated from children with diarrhea, but only 6% of isolates from healthy control, were of serotypes similar to those of enterotoxigenic E. coli isolated in previous studies of these pathogens by other investigators in geographically diverse areas (serotypes O6:H16, O8:H9, and O78:H12) (P less than 0.05). Eight (10%) of the children had infections with multiple enteric pathogens.
1976年1月至6月期间，在菲律宾因腹泻住院的82名儿童中，通过电子显微镜检测粪便中的病毒颗粒（82名中的12名[15%]）和/或血清学相关的内布拉斯加小牛腹泻病毒抗体滴度升高（39名中的8名[20%]），确定有14名（17%）感染了一种呼肠孤病毒样病原体。在82名患病儿童中有6名（7%）和49名健康对照儿童中有2名（4%）发现了产生不耐热肠毒素的大肠杆菌，而从3名腹泻儿童和2名无肠胃炎儿童中分离出了产生耐热肠毒素的大肠杆菌。从腹泻儿童中分离出的产肠毒素大肠杆菌中，38%的血清型与其他研究人员在不同地理区域对这些病原体进行的先前研究中分离出的产肠毒素大肠杆菌相似（血清型O6:H16、O8:H9和O78:H12），而从健康对照中分离出的菌株中只有6%相似（P<0.05）。8名（10%）儿童感染了多种肠道病原体。
