体内同种异体移植排斥反应的细胞基础。I. 心脏移植首次排斥反应的细胞需求。
The cellular basis of allograft rejection in vivo. I. The cellular requirements for first-set rejection of heart grafts.
作者信息
Hall B M, Dorsch S, Roser B
出版信息
J Exp Med. 1978 Oct 1;148(4):878-89. doi: 10.1084/jem.148.4.878.
Abstract
The nature of the cells required for first-set graft rejection in vivo was examined by using an adoptive transfer system to restore heart-graft rejection in irradiated rats. Highly purified inocula of peripheral T lymphocytes were shown to quantitatively account for the restorative ability of adoptively transferred cells. These T cells were shown to be long-lived small lymphocytes which are not recently derived from the thymus during adult life. They belong to the pool of T cells which constantly recirculate from blood to lymph as shown by their rapid appearance in the lymph of iradiated syngeneic rats after intravenous injection. Neither B lymphocytes nor antibodies in the circulation or in the graft itself are required for first-set graft rejection.
摘要
通过采用过继转移系统来恢复受辐照大鼠的心脏移植排斥反应，研究了体内初次移植排斥反应所需细胞的性质。结果表明，外周血T淋巴细胞的高度纯化接种物在数量上决定了过继转移细胞的恢复能力。这些T细胞是长寿的小淋巴细胞，并非成年期新近来源于胸腺。它们属于T细胞池，如静脉注射后在受辐照同基因大鼠的淋巴中迅速出现所示，这些T细胞不断地从血液再循环至淋巴。初次移植排斥反应不需要循环系统或移植组织本身中的B淋巴细胞或抗体。
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