鉴别大鼠胸导管中区分骨髓来源淋巴细胞和胸腺来源淋巴细胞的血清
The identification of sera distinguishing marrow-derived and thymus-derived lymphocytes in the rat thoracic duct.
作者信息
Howard J C, Scott D W
出版信息
Immunology. 1974 Nov;27(5):903-22.
Abstract
Grain count histograms from autoradiographs of [H]uridine-labelled rat thoracic duct lymphocytes confirm the previously reported difference in uridine uptake between thymus- and marrow-derived small lymphocytes in rats. This difference is used in conjunction with autoradiography to demonstrate the specificity of cytotoxic antisera distinguishing thymus- and marrow-derived small lymphocytes. Cytotoxic alloantisera detected a new polymorphic alloantigen system present on rat peripheral thymus-derived lymphocytes, but reduced or absent on thymocytes. At least three alleles or a complex genetic system are indicated. Rabbit antisera with specificity for rat marrow-derived small lymphocytes are described: these sera are not cytotoxic for haemolytic plaque-forming cells.
摘要
用[H]尿苷标记大鼠胸导管淋巴细胞的放射自显影片制作的颗粒计数直方图，证实了先前报道的大鼠胸腺来源和骨髓来源的小淋巴细胞在尿苷摄取方面的差异。这种差异与放射自显影相结合，用于证明区分胸腺来源和骨髓来源的小淋巴细胞的细胞毒性抗血清的特异性。细胞毒性同种抗血清检测到大鼠外周胸腺来源淋巴细胞上存在一种新的多态性同种抗原系统，但在胸腺细胞上减少或不存在。提示至少有三个等位基因或一个复杂的遗传系统。描述了对大鼠骨髓来源的小淋巴细胞具有特异性的兔抗血清：这些血清对溶血空斑形成细胞没有细胞毒性。
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2
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