Division of Translational Oncology, Department of Oncology, Hematology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, Tübingen, Germany.
Division of Translational Oncology, Department of Oncology, Hematology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, Tübingen, Germany.
Cell Rep Med. 2022 Aug 16;3(8):100724. doi: 10.1016/j.xcrm.2022.100724.
Most studies on leukemia focus on leukemia cells as isolated objects without considering the bone marrow niche. Pal et al. have recreated the bone marrow niche using induced pluripotent stem cells (iPSCs), identifying CDH2 as a therapeutically druggable leukemia-promoting factor..
大多数关于白血病的研究都集中在白血病细胞上，将其视为孤立的对象，而没有考虑骨髓微环境。Pal 等人利用诱导多能干细胞（iPSC）重新构建了骨髓微环境，确定 CDH2 是一种具有治疗潜力的促进白血病的因子。
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