骨髓间充质干细胞中的早幼粒细胞白血病蛋白对于白血病的进展是必不可少的。
Promyelocytic leukemia protein in mesenchymal stem cells is essential for leukemia progression.
机构信息
Department of Natural Sciences, Federal University of São João del Rei, São João Del Rey, MG, Brazil.
Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
出版信息
Ann Hematol. 2018 Oct;97(10):1749-1755. doi: 10.1007/s00277-018-3463-x. Epub 2018 Aug 1.
Abstract
The dynamic interactions between leukemic cells and cells resident within the bone marrow microenvironment are vital for leukemia progression. The lack of detailed knowledge about the cellular and molecular mechanisms involved in this cross-talk restricts the design of effective treatments. Guarnerio et al. (2018) by using state-of-the-art techniques, including sophisticated Cre/loxP technologies in combination with leukemia mouse models, reveal that mesenchymal stem cells via promyelocytic leukemia protein (Pml) maintain leukemic cells in the bone marrow niche. Strikingly, genetic deletion of Pml in mesenchymal stem cells raised survival of leukemic mice under chemotherapeutic treatment. The emerging knowledge from this research provides a novel target in the bone marrow niche for therapeutic benefit in leukemia.
摘要
白血病细胞与骨髓微环境中固有细胞之间的动态相互作用对白血病的进展至关重要。由于缺乏对这种串扰中涉及的细胞和分子机制的详细了解，限制了有效治疗方法的设计。Guarnerio 等人（2018 年）使用最先进的技术，包括复杂的 Cre/loxP 技术与白血病小鼠模型相结合，揭示了间充质干细胞通过早幼粒细胞白血病蛋白（Pml）维持骨髓龛中的白血病细胞。引人注目的是，间充质干细胞中 Pml 的基因缺失提高了接受化疗治疗的白血病小鼠的存活率。这项研究的新发现为白血病的骨髓龛治疗提供了一个新的靶点。
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