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分子水平上对 的高空适应和习服的认识。

Molecular insights into high-altitude adaption and acclimatisation of .

机构信息

Organisms and Environment, Cardiff University, Wales, UK

Wales Gene Park, Cardiff University, Wales, UK.

出版信息

Life Sci Alliance. 2022 Aug 17;5(11). doi: 10.26508/lsa.202201513. Print 2022 Nov.

Abstract

Here, we explore the high-altitude adaptions and acclimatisation of Population diversity is assessed through mitochondrial barcoding, identifying closely related populations across the island of Pico (Azores). We present the first megabase N50 assembly size (1.2 Mbp) genome for High- and low-altitude populations were exposed experimentally to a range of oxygen and temperature conditions, simulating altitudinal conditions, and the transcriptomic responses explored. SNP densities are assessed to identify signatures of selective pressure and their link to differentially expressed genes. The high-altitude population had lower differential expression and fewer co-expressed genes between conditions, indicating a more condition-refined epigenetic response. Genes identified as under adaptive pressure through F and nucleotide diversity in the high-altitude population clustered around the differentially expressed an upstream environmental response control gene, HMGB1. The high-altitude population of indicated adaption and acclimatisation to high-altitude conditions and suggested resilience to extreme weather events. understanding could help offer a strategy in further identifying other species capable of maintaining soil fertility in extreme environments.

摘要

在这里,我们探讨了人口多样性的高海拔适应和驯化,通过线粒体条形码进行评估,确定了皮科岛(亚速尔群岛)上的密切相关的种群。我们展示了第一个兆碱基 N50 组装大小(1.2 Mbp)基因组对于 高海拔和低海拔种群进行了实验暴露于一系列氧气和温度条件下,模拟海拔条件,并探索了转录组反应。评估 SNP 密度以确定选择压力的特征及其与差异表达基因的联系。高海拔种群在不同条件下的差异表达和共表达基因较少,表明其具有更精细的条件下的表观遗传反应。通过高海拔种群中的 F 和核苷酸多样性识别出受适应性压力影响的基因,聚类在差异表达的上游环境反应控制基因 HMGB1 周围。表明了 对高海拔条件的适应和驯化,并暗示对极端天气事件的恢复能力。 这一理解有助于提供一种策略,进一步确定其他能够在极端环境中维持土壤肥力的物种。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbba/9386962/47de88230c06/LSA-2022-01513_Fig1.jpg

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