Department of Neuro-Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Sci Rep. 2022 Aug 17;12(1):13976. doi: 10.1038/s41598-022-18242-4.
An easily accessible biomarker with good diagnostic power for patients with traumatic brain injury (TBI) was needed to predict the short-term mortality. Studies have shown that platelet-to-lymphocyte ratio (PLR) is a biomarker for patients with tumor. This study aimed to identify the relationship between PLR and short-term mortality in patients with moderate to severe TBI. This is a retrospective cohort study. We selected patients with moderate to severe TBI who were admitted to the emergency department of The First Affiliated Hospital of Zhengzhou University. Biomarkers were collected within 24 h after admission. To investigate their relationship with short-term mortality, Cox proportional hazards regression and ROC curve analysis were performed. A total number of 170 patients was included. 47 (27.6%) patients had died and 123 (72.4%) patients were survived by the end of the study. Patients with different Rotterdam CT score (HR = 1.571, 95%CI 1.232-2.002, p < 0.001) or PLR levels (HR = 1.523, 95%CI 1.110-2.090, p = 0.009) had significant different mortality rates. The AUC curve analysis showed that the AUC of Rotterdam CT score and PLR groups were 0.729 (95%CI 0.638-0.821, p < 0.001) and 0.711 (95%CI 0.618-0.803 p < 0.001), respectively. PLR level is an independent biomarker with great diagnostic power for short-term mortality in patients with moderate to severe brain injury.
一种易于获取且具有良好诊断效能的生物标志物，用于预测创伤性脑损伤（TBI）患者的短期死亡率。已有研究表明血小板与淋巴细胞比值（PLR）是肿瘤患者的一种生物标志物。本研究旨在确定 PLR 与中重度 TBI 患者短期死亡率之间的关系。这是一项回顾性队列研究。我们选择了因中重度 TBI 而收入郑州大学第一附属医院急诊科的患者。在入院后 24 小时内采集了生物标志物。为了研究它们与短期死亡率的关系，进行了 Cox 比例风险回归和 ROC 曲线分析。共纳入 170 例患者。其中 47 例（27.6%）患者死亡，123 例（72.4%）患者在研究结束时存活。不同 Rotterdam CT 评分（HR=1.571，95%CI 1.232-2.002，p<0.001）或 PLR 水平（HR=1.523，95%CI 1.110-2.090，p=0.009）的患者死亡率存在显著差异。AUC 曲线分析表明，Rotterdam CT 评分组和 PLR 组的 AUC 分别为 0.729（95%CI 0.638-0.821，p<0.001）和 0.711（95%CI 0.618-0.803，p<0.001）。PLR 水平是一种独立的生物标志物，对中重度脑损伤患者的短期死亡率具有较高的诊断效能。
