School of Biological Science and Technology, University of Jinan, Jinan, 250022, People's Republic of China.
RZBC GROUP CO., LTD., Rizhao, 276800, Shandong, China.
World J Microbiol Biotechnol. 2022 Aug 18;38(11):192. doi: 10.1007/s11274-022-03382-6.
With advantages of low substrates cost, high optical purity of end products and environmentally friendly fermentation process, microbial production of valuable chemicals grow rapidly. Compared with static microbial strain engineering strategies, such as gene deletion, overexpression and mutation, dynamic pathway regulation is a new approach that balances cellular growth and chemical production. Quorum sensing is a natural microbial communication system responsible for cell-density-related cell behaviors. Accordingly, quorum sensing systems can be employed to achieve dynamic regulation in microorganisms without the need for manual intervention or the use of chemical inducers. In this review, natural quorum sensing systems are firstly summarized. Then, recent progress in using quorum sensing circuits in the field of metabolic engineering is highlighted. The current application challenges of quorum sensing systems and future perspectives in microbial synthesis of chemicals are also discussed.
具有底物成本低、产物光学纯度高、发酵过程环保等优点，微生物生产有价值的化学品发展迅速。与静态微生物菌株工程策略（如基因缺失、过表达和突变）相比，动态途径调控是一种新的方法，可以平衡细胞生长和化学物质的生产。群体感应是一种负责与细胞密度相关的细胞行为的天然微生物通讯系统。因此，群体感应系统可以在无需人工干预或使用化学诱导剂的情况下，在微生物中实现动态调节。在这篇综述中，首先总结了天然群体感应系统。然后，重点介绍了群体感应电路在代谢工程领域的最新进展。还讨论了群体感应系统的当前应用挑战和微生物合成化学品的未来展望。
