Shi Yanan, Xu Xiao, Liu Ting, Wang Rongyun, Xu Jingming, Wu Yujing, Ding Bin, Sun Qiuhua
The College of Nursing, Zhejiang Chinese Medical University, Hangzhou 310053, China.
The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Evid Based Complement Alternat Med. 2022 Aug 8;2022:2823315. doi: 10.1155/2022/2823315. eCollection 2022.
Postoperative ileus (POI) is a common surgical complication, and its incidence remains high. Shenhuang Plaster (SHP) is a famous traditional Chinese medicine with a definite curative effect on postoperative intestinal dysfunction; however, the mechanisms involved in these effects are unclear. Accordingly, in this study, we constructed a POI mouse model and used the intestinal flora as the target to explore the regulatory effect of SHP on gastrointestinal motility. The results illustrated that SHP applied at the Shenque acupoint promoted the recovery of gastrointestinal motility, relieved intestinal villus atrophy and basal damage caused by POI, protected the integrity of intestinal tissue morphology, and alleviated the inflammatory response in the intestinal tissue of POI model mice. In addition, we clarified the role of the intestinal flora in the occurrence and development of POI, further evaluated the changes in the intestinal flora in each group of mice, and analysed the regulatory effect of SHP on the intestinal flora in mice with POI. The results suggested that SHP might improve gastrointestinal motility disorder in POI mice by effectively regulating intestinal flora.
术后肠梗阻（POI）是一种常见的手术并发症，其发生率仍然很高。神阙膏（SHP）是一种著名的中药，对术后肠道功能障碍有确切疗效；然而，这些作用所涉及的机制尚不清楚。因此，在本研究中，我们构建了POI小鼠模型，并以肠道菌群为靶点，探讨SHP对胃肠动力的调节作用。结果表明，在神阙穴应用SHP可促进胃肠动力恢复，减轻POI引起的肠绒毛萎缩和基底损伤，保护肠组织形态的完整性，并减轻POI模型小鼠肠组织的炎症反应。此外，我们阐明了肠道菌群在POI发生发展中的作用，进一步评估了每组小鼠肠道菌群的变化，并分析了SHP对POI小鼠肠道菌群的调节作用。结果提示，SHP可能通过有效调节肠道菌群来改善POI小鼠的胃肠动力障碍。
