Lai Wilson C, Bohlen Hunter L, Fackler Nathan P, Wang Dean
Department of Orthopaedic Surgery, UCI Health, Orange, CA, USA.
Georgetown University School of Medicine, Washington, DC, USA.
Orthop Res Rev. 2022 Aug 11;14:263-274. doi: 10.2147/ORR.S253761. eCollection 2022.
Knee articular cartilage defects can result in significant pain and loss of function in active patients. Osteochondral allograft (OCA) transplantation offers a single-stage solution to address large chondral and osteochondral defects by resurfacing focal cartilage defects with mature hyaline cartilage. To date, OCA transplantation of the knee has demonstrated excellent clinical outcomes and long-term survivorship. However, significant variability still exists among clinicians with regard to parameters for graft acceptance, surgical technique, and rehabilitation. Technologies to optimize graft viability during storage, improve osseous integration of the allograft, and shorten recovery timelines after surgery continue to evolve. The purpose of this review is to examine the latest evidence on treatment indications, graft storage and surgical technique, patient outcomes and survivorship, and rehabilitation after surgery.
膝关节软骨缺损会给活跃的患者带来严重疼痛和功能丧失。骨软骨异体移植（OCA）通过用成熟的透明软骨修复局部软骨缺损，为解决大面积软骨和骨软骨缺损提供了一种单阶段解决方案。迄今为止，膝关节的OCA移植已显示出优异的临床效果和长期存活率。然而，在移植物接受参数、手术技术和康复方面，临床医生之间仍存在显著差异。优化移植物储存期间活力、改善异体骨整合以及缩短术后恢复时间的技术仍在不断发展。本综述的目的是研究关于治疗适应症、移植物储存和手术技术、患者预后和存活率以及术后康复的最新证据。
