Nordberg Rachel C, Wen Deborah H, Wang Dean, Hu Jerry C, Athanasiou Kyriacos A
Department of Biomedical Engineering, University of California Irvine, Irvine, California, USA.
Department of Orthopaedic Surgery, University of California Irvine Medical Center, Orange, CA, USA.
Curr Opin Biomed Eng. 2024 Sep;31. doi: 10.1016/j.cobme.2024.100546. Epub 2024 May 18.
Due to the high incidence of cartilage-related pathologies such as focal defects and osteoarthritis, strategies are needed to restore the structure and function of osteochondral tissue. Articular cartilage and bone have distinctly different properties, rendering challenging the engineering of a robust interface that reduces stress concentrations and delamination. The osteochondral interface, which consists of a tidemark, calcified cartilage, cement line, and surrounding tissues, has a unique structure and function, but there is a dearth of quantitative data to describe it. Elucidating the structure-function relationships through characterization will be essential in defining design criteria for tissue engineering. Osteochondral engineering has used scaffold-based methods that, for example, use polymers in conjunction with ceramics. Excitingly, scaffold-free methods are emerging for engineering the articular cartilage layer, which can be interfaced with an underlying bone substrate. Critical must be the objective of designing an interface that displays mechanics robust enough to withstand the native environment.
由于诸如局灶性缺损和骨关节炎等软骨相关病症的高发病率，需要采取策略来恢复骨软骨组织的结构和功能。关节软骨和骨骼具有明显不同的特性，这使得构建一个能减少应力集中和分层的坚固界面具有挑战性。骨软骨界面由潮线、钙化软骨、黏合线和周围组织组成，具有独特的结构和功能，但缺乏描述它的定量数据。通过表征来阐明结构 - 功能关系对于定义组织工程的设计标准至关重要。骨软骨工程采用了基于支架的方法，例如将聚合物与陶瓷结合使用。令人兴奋的是，正在出现用于构建关节软骨层的无支架方法，该软骨层可与下方的骨基质相接。设计一个力学性能足够强大以承受自然环境的界面必定是关键目标。
