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紫苏甲氧基黄酮诱导 A549 人肺腺癌细胞而非正常人支气管上皮细胞衰老。

A Methoxyflavanone from Perilla frutescens Induces Cellular Senescence in A549 Human Lung Adenocarcinoma Cells but Not in Normal Human Bronchial Epithelial Cells.

机构信息

Hiroshima Research Center for Healthy Aging (HiHA), Unit of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University.

Mishima Foods Co., Ltd.

出版信息

Biol Pharm Bull. 2022 Oct 1;45(10):1581-1584. doi: 10.1248/bpb.b22-00310. Epub 2022 Aug 18.

DOI:10.1248/bpb.b22-00310
PMID:35979561
Abstract

Cellular senescence is an inherent tumor suppressive process, and cancer-targeted senescence induction represents an attractive anti-tumor strategy. Here, we show that a methoxyflavanone derivative (Perilla-derived methoxyflavanone, PDMF) from the Asian medicinal herb, Perilla frutescens, induces cellular senescence in A549 human adenocarcinoma cells but not in normal human bronchial epithelial (NHBE) cells. We also provide evidence that PDMF preferentially activates the p53-p21 pathway in A549 cells, and that p53 is essential for its pro-senescent activity.

摘要

细胞衰老（cellular senescence）是一种内在的肿瘤抑制过程，针对肿瘤的衰老诱导代表了一种有吸引力的抗肿瘤策略。在这里，我们表明，来源于亚洲药用植物紫苏（Perilla frutescens）的甲氧基查尔酮衍生物（methoxyflavanone derivative），能够诱导人肺腺癌细胞 A549 发生细胞衰老，但不能诱导正常的人支气管上皮细胞（NHBE）发生细胞衰老。我们还提供了证据表明，PDMF 优先在 A549 细胞中激活 p53-p21 通路，并且 p53 对于其促进衰老的活性是必需的。

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