脂肪组织对面部衰老的作用。
Role of adipose tissue in facial aging.
机构信息
Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden.
Department of Anesthesiology and Intensive Care Medicine, and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.
出版信息
Clin Interv Aging. 2017 Dec 6;12:2069-2076. doi: 10.2147/CIA.S151599. eCollection 2017.
Abstract
Age-dependent modification of the facial subcutaneous white adipose tissue (sWAT) connected with reduction of its volume, modification of collagen content and adhesion between dermal and adipose layers can significantly influence mechanical stability of the skin and cause the development of aging symptoms such as wrinkles. Typical aging appearance in facial skin is at least partly connected with special phenotypical features of facial preadipocytes and mature adipocytes. In this paper, we have discussed the possible roles of local inflammation, compartmental structure of facial sWAT and trans-differentiation processes such as beiging of white adipocytes and adipocyte-myofibroblast transition in facial skin aging.
摘要
年龄相关的面部皮下白色脂肪组织（sWAT）的改变，伴随着其体积的减少、胶原蛋白含量的改变以及真皮和脂肪层之间的粘连，会显著影响皮肤的机械稳定性，并导致皱纹等衰老症状的发展。面部皮肤的典型衰老外观至少部分与面部前脂肪细胞和成熟脂肪细胞的特殊表型特征有关。在本文中，我们讨论了局部炎症、面部 sWAT 的隔室结构以及白色脂肪细胞的褐变和脂肪细胞-肌成纤维细胞转化等转分化过程在面部皮肤衰老中的可能作用。
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