Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), San Juan de Alicante, Alicante, Spain.
Science. 2022 Aug 19;377(6608):845-850. doi: 10.1126/science.abq2960. Epub 2022 Aug 18.
Whereas sensory perception relies on specialized sensory pathways, it is unclear whether these pathways originate as modality-specific circuits. We demonstrated that somatosensory and visual circuits are not by default segregated but require the earliest retinal activity to do so. In the embryo, somatosensory and visual circuits are intermingled in the superior colliculus, leading to cortical multimodal responses to whisker pad stimulation. At birth, these circuits segregate, and responses switch to unimodal. Blocking stage I retinal waves prolongs the multimodal configuration into postnatal life, with the superior colliculus retaining a mixed somato-visual molecular identity and defects arising in the spatial organization of the visual system. Hence, the superior colliculus mediates the timely segregation of sensory modalities in an input-dependent manner, channeling specific sensory cues to their appropriate sensory pathway.
虽然感觉感知依赖于专门的感觉通路，但这些通路是否起源于特定模式的电路尚不清楚。我们证明，感觉和视觉通路并非默认分离，而是需要最早的视网膜活动才能实现分离。在胚胎中，感觉和视觉通路在顶盖中交织在一起，导致对触须垫刺激的皮层多模态反应。出生后，这些回路分离，反应转变为单模态。阻断 I 期视网膜波会将多模态结构延长到出生后，顶盖保留混合的躯体-视觉分子特征，而视觉系统的空间组织出现缺陷。因此，顶盖以依赖于输入的方式介导感觉模态的及时分离，将特定的感觉线索引导到适当的感觉通路。
