Riazi-Rad Farhad, Behrouzi Ava, Mazaheri Hoora, Katebi Asal, Ajdary Soheila
1Department of Immunology, Pasteur Institute of Iran, Tehran, Iran.
2Department of Microbiology, Faculty of Advanced Science and Technology, Tehran Medical Science, Islamic Azad University, Tehran, Iran.
Acta Microbiol Immunol Hung. 2021 Aug 10. doi: 10.1556/030.2021.01532.
The commensal microflora collection known as microbiota has an essential role in maintaining the host's physiological homeostasis. The microbiota has a vital role in induction and regulation of local and systemic immune responses. On the other hand, the immune system involves maintaining microbiota compositions. Optimal microbiota-immune system cross-talk is essential for protective responses to pathogens and immune tolerance to self and harmless environmental antigens. Any change in this symbiotic relationship may cause susceptibility to diseases. The association of various cancers and auto-immune diseases with microbiota has been proven. Here we review the interaction of immune responses to gut microbiota, focusing on innate and adaptive immune system and disease susceptibility.
被称为微生物群的共生微生物集合在维持宿主的生理稳态中起着至关重要的作用。微生物群在局部和全身免疫反应的诱导和调节中发挥着重要作用。另一方面，免疫系统参与维持微生物群的组成。微生物群与免疫系统之间的最佳相互作用对于对病原体的保护性反应以及对自身和无害环境抗原的免疫耐受至关重要。这种共生关系的任何变化都可能导致对疾病的易感性。各种癌症和自身免疫性疾病与微生物群的关联已得到证实。在这里，我们综述了针对肠道微生物群的免疫反应的相互作用，重点关注先天性和适应性免疫系统以及疾病易感性。
