亚精胺的摄入量与老年人的大脑皮质厚度和海马体体积有关。

Spermidine intake is associated with cortical thickness and hippocampal volume in older adults.

机构信息

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, NeuroCure Clinical Research Center, Berlin, Germany.

出版信息

Neuroimage. 2020 Nov 1;221:117132. doi: 10.1016/j.neuroimage.2020.117132. Epub 2020 Jul 3.

DOI:10.1016/j.neuroimage.2020.117132

PMID:32629145

Abstract

BACKGROUND

The natural polyamine spermidine, known to be important for cellular function, decreases during aging. Previous research has demonstrated beneficial impact of spermidine intake on memory functions in both animal models and humans, suggesting that spermidine may be a preventive approach to delay age-related cognitive decline and possibly even Alzheimer's disease (AD). However, the association of spermidine intake with brain health in humans is still unknown. In this study, we aimed to determine the association between dietary spermidine intake and structural brain measures in older individuals with subjective cognitive decline (SCD) and healthy controls (HC).

METHODS

Dietary spermidine intake and adherence to Mediterranean Diet (MeDi) were assessed by a self-reported food frequency questionnaire in 90 older adults with SCD and 47 HC. Processing of structural MRI data yielded global brain volumes, hippocampal volume, mean and regional cortical thickness, and cortical thickness in a template encompassing AD-vulnerable regions. In exploratory analyses, the association between spermidine intake and structural brain measures was assessed using adjusted and unadjusted linear regression models. Additionally, we tested for differential associations as a function of group. Mediation analyses were performed to examine whether dietary spermidine intake mediates the associations between adherence to MeDi and structural brain measures.

RESULTS

Higher spermidine intake was associated with larger hippocampal volume (standardized β = 0.262, p = 0.002), greater mean cortical thickness (standardized β = 0.187, p = 0.031), and greater cortical thickness in AD-vulnerable brain regions (standardized β = 0.176, p = 0.042), the parietal (standardized β = 0.202, p = 0.020), and temporal lobes (standardized β = 0.217, p = 0.012). No significant differential effect emerged between older adults with SCD and HC. Moreover, a substantial mediating effect of dietary spermidine intake on the associations between adherence to MeDi and structural brain measures was observed.

CONCLUSION

Higher dietary spermidine intake was positively associated with several structural brain measures, irrespective of the presence of SCD, and substantially mediated the relationship of adherence to MeDi and structural brain measures. Our data suggest that higher spermidine intake might be a promising dietary approach to preserve brain health in older adults, a hypothesis currently tested in an interventional trial.

摘要

背景

天然多胺亚精胺对细胞功能很重要，其含量会随着衰老而降低。先前的研究表明，亚精胺的摄入对动物模型和人类的记忆功能有有益影响，这表明亚精胺可能是一种预防措施，可以延缓与年龄相关的认知能力下降，甚至可能预防阿尔茨海默病（AD）。然而，亚精胺的摄入与人类大脑健康的关联尚不清楚。在这项研究中，我们旨在确定在有主观认知衰退（SCD）的老年人和健康对照组（HC）中，饮食中亚精胺的摄入量与结构性大脑测量之间的关联。

方法

通过自我报告的食物频率问卷评估 90 名老年人 SCD 和 47 名 HC 的饮食中亚精胺的摄入量和对地中海饮食（MeDi）的依从性。对结构磁共振成像数据的处理得出了大脑总体积、海马体积、皮质平均厚度和皮质厚度，以及包含 AD 易损区域的模板中的皮质厚度。在探索性分析中，使用调整和未调整的线性回归模型评估了亚精胺摄入量与结构性大脑测量之间的关联。此外，我们还测试了是否存在群体差异。进行中介分析以检查饮食中亚精胺的摄入量是否介导了对 MeDi 的依从性与结构性大脑测量之间的关联。

结果

较高的亚精胺摄入量与较大的海马体体积（标准化 β = 0.262，p = 0.002）、较大的皮质平均厚度（标准化 β = 0.187，p = 0.031）和 AD 易损大脑区域的较大皮质厚度（标准化 β = 0.176，p = 0.042）、顶叶（标准化 β = 0.202，p = 0.020）和颞叶（标准化 β = 0.217，p = 0.012）相关。在 SCD 老年人和 HC 之间没有出现显著的差异效应。此外，饮食中亚精胺的摄入量对 MeDi 依从性与结构性大脑测量之间的关联具有实质性的中介作用。