Haddout S, Imami Y, Benhessou M, Ennachit M, El Karroumi M
Mohamed VI Cancer Treatment Center, Ibn Rochd University Hospital of Casablanca, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.
Mohamed VI Cancer Treatment Center, Ibn Rochd University Hospital of Casablanca, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco.
Int J Surg Case Rep. 2022 Sep;98:107460. doi: 10.1016/j.ijscr.2022.107460. Epub 2022 Jul 26.
Primary vaginal cancers are rare and clear cell adenocarcinoma is a malignant tumor that is all the more rare when the woman has not been exposed in utero to synthetic diethylstilboestrol (DES). We report the case of a 60-year-old woman with a history of balanced essential hypertension and partial mastectomy for neoplasia, who presented with a recurrent left inguinal adenopathy. Clinical examination revealed a 3 cm bulging lesion of the anterior vaginal wall in the lower third with indurated left inguinal adenopathy. Biopsy of the nodule showed an invasive clear cell adenocarcinoma. The extension bialn is negative and the multidisciplinary decision is to perform a partial colpectomy with bilateral inguinal curage. The patient is currently undergoing radiochemotherapy. This is a rare case with a poor prognosis. A poor response to adjuvant therapy with a high frequency of distant metastases is reported in the literature. Due to the rarity of this pathology, individual experience based on case reports is the main source of information. The most effective mode of treatment therefore remains unknown and depends on patient-specific factors such as tumor size, surgeon and oncologist team experiences.
原发性阴道癌罕见，而透明细胞腺癌是一种恶性肿瘤，当女性在子宫内未接触过合成己烯雌酚（DES）时则更为罕见。我们报告了一例60岁女性病例，她有原发性高血压病史且因肿瘤接受过部分乳房切除术，现出现左侧腹股沟淋巴结复发。临床检查发现阴道下三分之一前壁有一个3厘米的隆起病变，左侧腹股沟淋巴结变硬。结节活检显示为浸润性透明细胞腺癌。双侧扩展检查为阴性，多学科会诊决定行部分阴道切除术及双侧腹股沟淋巴结清扫术。患者目前正在接受放化疗。这是一例预后不良的罕见病例。文献报道辅助治疗反应不佳，远处转移频率高。由于这种病理情况罕见，基于病例报告的个人经验是主要信息来源。因此，最有效的治疗方式仍然未知，且取决于肿瘤大小、外科医生和肿瘤学家团队经验等患者特异性因素。
