Baloi Denise, Smith William J, Samyn Robin
Department of Family Medicine, Michigan State University College of Human Medicine, East Lansing, USA.
Department of Pathology, Detroit Medical Center, Wayne State University School of Medicine, Detroit, USA.
Cureus. 2024 Dec 20;16(12):e76083. doi: 10.7759/cureus.76083. eCollection 2024 Dec.
Clear cell adenocarcinoma of the cervix (CCAC) is a rare subtype of cervical adenocarcinoma. It has been linked to intrauterine exposure to diethylstilbestrol (DES) but can happen in non-DES-exposed patients, albeit less commonly. Presentation is largely vaginal bleeding, emphasizing the importance of considering CCAC in the differential of abnormal vaginal bleeding despite the tumor's rarity. We present the case of a non-DES-exposed 68-year-old woman who presented with postmenopausal bleeding (PMB). The patient underwent total abdominal hysterectomy after misdiagnosis as clear cell endometrial adenocarcinoma, later diagnosed as CCAC. We encourage consideration of clear cell adenocarcinoma of the cervix in the differential diagnosis of PMB even in patients without DES exposure and for physicians to advocate for patients to keep up to date with cervical cancer screenings.
宫颈透明细胞腺癌（CCAC）是宫颈腺癌的一种罕见亚型。它与子宫内接触己烯雌酚（DES）有关，但在未接触DES的患者中也可能发生，尽管较为少见。主要表现为阴道出血，这凸显了尽管该肿瘤罕见，但在异常阴道出血的鉴别诊断中考虑CCAC的重要性。我们报告一例68岁未接触DES的女性患者，她出现绝经后出血（PMB）。该患者在被误诊为透明细胞子宫内膜腺癌后接受了全腹子宫切除术，后来被诊断为CCAC。我们鼓励即使在未接触DES的患者中，在PMB的鉴别诊断中也考虑宫颈透明细胞腺癌，并鼓励医生倡导患者定期进行宫颈癌筛查。
