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橙皮苷:药理学作用综述。

Eriocitrin: A review of pharmacological effects.

机构信息

Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China.

University and College Key Lab of Natural Product Chemistry and Application in Xinjiang, School of Chemistry and Environmental Science, Yili Normal University, Yining 835000, China.

出版信息

Biomed Pharmacother. 2022 Oct;154:113563. doi: 10.1016/j.biopha.2022.113563. Epub 2022 Aug 18.

Abstract

The present study aimed to recognize the recent literature to highlight the pharmacological impacts and highlight the therapeutic potential of the active molecule eriocitrin. Citrus limon are a good resource of the flavanone eriocitrin (eriodictyol 7-O-β-D-rutinoside). Eriocitrin has potent biological actions due to its strong antioxidant, antitumor, anti-allergic, antidiabetic and anti-inflammatory activities. Eriocitrin is more potent in suppressing oxidative stress in diabetes mellitus (DM) and other chronic diseases incurred by excessive oxidative stress. During metabolism, eriocitrin is metabolized by gut microbiota, and a chain of molecules such as eriodictyol, methy-eriodictyol, 3,4-dihydroxyhydrocinnamic acid (DHCA), and much more conjugated molecules. More in-depth studies are recommended to explore this drug for clinical trials.

摘要

本研究旨在综述近期文献,强调活性分子圣草枸橼苷的药理学作用,并突出其治疗潜力。柠檬是类黄酮圣草枸橼苷(柚皮苷 7-O-β-D-新橙皮糖苷)的良好来源。圣草枸橼苷具有很强的抗氧化、抗肿瘤、抗变态反应、抗糖尿病和抗炎作用,因此具有很强的生物学活性。圣草枸橼苷在抑制糖尿病(DM)和其他由过度氧化应激引起的慢性疾病的氧化应激方面更为有效。在代谢过程中,圣草枸橼苷被肠道微生物群代谢,生成一系列分子,如柚皮素、甲基柚皮素、3,4-二羟基肉桂酸(DHCA)和更多的共轭分子。建议进行更深入的研究,以探索这种药物用于临床试验。

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