Department of Emergency, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, China.
Heart Function Examination Room, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, China.
Front Endocrinol (Lausanne). 2022 Aug 8;13:946982. doi: 10.3389/fendo.2022.946982. eCollection 2022.
FNDC5 is a novel and important player in energy regulation related to glucose metabolism and insulin levels. Thus, it may affect the incidence of type 2 diabetes mellitus (T2DM). Nevertheless, the association between FNDC5 single nucleotide polymorphisms (SNPs) and susceptibility to T2DM remains unclear. The aim of this meta-analysis was to explore whether the SNPs, rs3480 and rs16835198, are associated with the risk of T2DM.
Studies published before February 1, 2022 were screened to identify the included studies. R software was also applied for calculation of odds ratio (OR), 95% confidence interval (95% CI), heterogeneity, and sensitivity analysis.
Seven studies for rs3480 (involving 5475 patients with T2DM and 4855 healthy controls) and five studies for rs16835198 (involving 4217 patients with T2DM and 4019 healthy controls) were included in this meta-analysis. The results revealed a statistically significant association of rs3480 with T2DM under homozygote (GG vs AA: OR = 1.76, 95% CI = 1.31-2.37, = 0.0002, I = 59%) genetic model. However, there was no statistically significant correlation between rs16835198 and susceptibility to T2DM under allelic (G vs T: OR = 1.33, 95% CI = 0.94-1.89, = 0.11, I = 84%), heterozygote (GT vs TT: OR = 1.17, 95% CI = 0.80-1.69, = 0.42, I = 71%), homozygote (GG vs TT: OR = 1.35, 95% CI = 0.95-1.94, = 0.10, I = 62%), recessive (GG+GT vs TT: OR = 1.25, 95% CI = 0.88-1.79, = 0.22, I = 72%), and dominant (GG vs GT+GG: OR = 1.20, 95% CI = 0.96-1.50, = 0.11, I = 46%) genetic models.
The present meta-analysis revealed that rs3480 in FNDC5 is significantly associated with susceptibility to T2DM, while rs16835198 does not show such an association.
FNDC5 是一种与葡萄糖代谢和胰岛素水平相关的能量调节的新型重要因子。因此，它可能会影响 2 型糖尿病（T2DM）的发病风险。然而，FNDC5 单核苷酸多态性（SNP）与 T2DM 易感性之间的关联仍不清楚。本荟萃分析旨在探讨 rs3480 和 rs16835198 这两个 SNP 是否与 T2DM 的发病风险相关。
筛选截止到 2022 年 2 月 1 日之前发表的研究，以确定纳入的研究。还应用 R 软件计算比值比（OR）、95%置信区间（95%CI）、异质性和敏感性分析。
本荟萃分析纳入了 7 项关于 rs3480（涉及 5475 例 T2DM 患者和 4855 例健康对照者）和 5 项关于 rs16835198（涉及 4217 例 T2DM 患者和 4019 例健康对照者）的研究。结果显示，在同型合子（GG 与 AA：OR=1.76，95%CI=1.31-2.37， =0.0002，I=59%）遗传模型下，rs3480 与 T2DM 显著相关。然而，在等位基因（G 与 T：OR=1.33，95%CI=0.94-1.89， =0.11，I=84%）、杂合子（GT 与 TT：OR=1.17，95%CI=0.80-1.69， =0.42，I=71%）、同型合子（GG 与 TT：OR=1.35，95%CI=0.95-1.94， =0.10，I=62%）、隐性（GG+GT 与 TT：OR=1.25，95%CI=0.88-1.79， =0.22，I=72%）和显性（GG 与 GT+GG：OR=1.20，95%CI=0.96-1.50， =0.11，I=46%）遗传模型下，rs16835198 与 T2DM 易感性之间均无显著相关性。
本荟萃分析表明，FNDC5 中的 rs3480 与 T2DM 的易感性显著相关，而 rs16835198 则无此相关性。
