Tsubokawa Masaya, Nishimura Miyuki, Mikami Tatsuya, Ishida Mizuri, Hisada Takayoshi, Tamada Yoshinori
Innovation Center for Health Promotion, Graduate School of Medicine, Hirosaki University, Hirosaki City 036-8562, Japan.
Health Science Research Center, FANCL Research Institute, Yokohama City 244-0806, Japan.
Metabolites. 2022 Aug 7;12(8):730. doi: 10.3390/metabo12080730.
The gut microbiota has become a significant factor associated with health and disease. Although many studies have reported the implications of changes in the gut microbiota on cardiovascular diseases, there are no reports on the relationship between heart rate variability (HRV) and the gut microbiota. Therefore, we investigated the association between gut microbiota abundance and HRV parameters in this cross-sectional study of the general Japanese population. This study included 950 participants of the Iwaki Health Promotion Project who underwent a medical examination in 2019 that included HRV and gut microbiota measurements. At the genus level, multivariate regression analysis showed that higher gut microbial diversity was associated with a higher standard deviation of RR intervals (SDNN). Moreover, a higher SDNN was associated with a higher relative count of . abundance was associated with higher HRV parameters such as SDNN, coefficient of variation of RR intervals, low-frequency component power (LF)/high-frequency component power, and LF. In the general Japanese population, higher gut microbial diversity and abundance were associated with higher HRV parameters.
肠道微生物群已成为与健康和疾病相关的一个重要因素。尽管许多研究报告了肠道微生物群变化对心血管疾病的影响，但关于心率变异性（HRV）与肠道微生物群之间的关系尚无报道。因此，在这项针对日本普通人群的横断面研究中，我们调查了肠道微生物群丰度与HRV参数之间的关联。本研究纳入了岩城健康促进项目的950名参与者，他们在2019年接受了包括HRV和肠道微生物群测量在内的医学检查。在属水平上，多变量回归分析表明，较高的肠道微生物多样性与RR间期标准差（SDNN）较高有关。此外，较高的SDNN与较高的 相对计数有关。 丰度与较高的HRV参数有关，如SDNN、RR间期变异系数、低频成分功率（LF）/高频成分功率和LF。在日本普通人群中，较高的肠道微生物多样性和 丰度与较高的HRV参数有关。
