Wiegmann Anja, Rinaud Tony, Ottensmann Meinolf, Krüger Oliver, Springer Andrea, Legler Marko, Fehr Michael, Strube Christina, Chakarov Nayden
Department of Animal Behaviour, Bielefeld University, Konsequenz 45, 33615 Bielefeld, Germany.
Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, Buenteweg 17, 30559 Hannover, Germany.
Vet Sci. 2022 Jul 30;9(8):397. doi: 10.3390/vetsci9080397.
Differences in drug tolerability among vertebrate groups and species can create substantial challenges for wildlife and ex situ conservation programmes. Knowledge of tolerance in the use of new drugs is, therefore, important to avoid severe toxicity in species, which are both commonly admitted in veterinary clinics and are of conservation concern. Antimalarial drugs have been developed for use in human medicine, but treatment with different agents has also long been used in avian medicine, as haemosporidian infections play a major role in many avian species. This study investigates the effects of the application of atovaquone-proguanil (Malarone, GlaxoSmithKline) in common buzzards (). The potential effects of treatment on body condition, growth rate, and chemical blood parameters of nestlings were assessed. All individuals survived the treatment, and no effects on body condition, growth rate, and chemical blood parameters were observed. Our results suggest the tolerability of Malarone in common buzzards at a single dose of on average 11 mg/kg body weight. For its safe use, we recommend further studies to determine pharmacokinetics in different avian species as well as to assess the effects of repeated treatment.
脊椎动物群体和物种之间在药物耐受性上的差异会给野生动物和迁地保护项目带来巨大挑战。因此，了解新药使用中的耐受性对于避免在兽医诊所常见且受保护关注的物种中出现严重毒性很重要。抗疟药物已开发用于人类医学，但不同药物的治疗也长期用于鸟类医学，因为血孢子虫感染在许多鸟类物种中起主要作用。本研究调查了阿托伐醌-氯胍（玛拉罗，葛兰素史克）在普通鵟中的应用效果。评估了治疗对雏鸟身体状况、生长速率和血液化学参数的潜在影响。所有个体在治疗后存活，未观察到对身体状况、生长速率和血液化学参数的影响。我们的结果表明，普通鵟对平均单剂量11毫克/千克体重的玛拉罗具有耐受性。为确保其安全使用，我们建议进一步开展研究以确定不同鸟类物种的药代动力学，并评估重复治疗的效果。
