Departamento de fisioterapia, Laboratório de Inovação Tecnológica em Reabilitação e PneumoCardioVascular Lab/HUOL, Hospital Universitário Onofre Lopes, Empresa Brasileira de Serviços Hospitalares (EBSERH), Universidade Federal do Rio Grande do Norte, Natal, Brazil
Departamento de fisioterapia, Laboratório de Inovação Tecnológica em Reabilitação e PneumoCardioVascular Lab/HUOL, Hospital Universitário Onofre Lopes, Empresa Brasileira de Serviços Hospitalares (EBSERH), Universidade Federal do Rio Grande do Norte, Natal, Brazil.
BMJ Open. 2022 May 30;12(5):e061624. doi: 10.1136/bmjopen-2022-061624.
Respiratory muscle weakness and ventilatory failure are common complications in patients with amyotrophic lateral sclerosis (ALS) and may lead to death. Respiratory physiotherapy may improve lung function in this population. This study aims to investigate the effects of respiratory physiotherapy on lung function, cough efficacy and functional status of patients with ALS.
A protocol was published on the International prospective register of systematic reviews (PROSPERO). The research will cover randomised controlled trials, with no language or publication date restriction, available in the following databases: MEDLINE/PubMed, EMBASE, Cochrane Library, Web of Science and Physiotherapy Evidence Database. The research question will be answered using a search strategy adapted for each database. Searches in databases will be conducted from January 2021 to December 2022. Two authors using the Cochrane risk of bias tool for randomised trials V.2 and Grading of Recommendations, Assessment, Development and Evaluations, respectively, will assess risk of bias and quality of evidence independently. According to the results obtained, data will be reported as a meta-analysis or a narrative report.
No previous ethical approval is required for this publication since data used are already published. Results of this review will be disclosed via peer-reviewed publications and conference presentations.
CRD42021251842.
呼吸肌无力和通气衰竭是肌萎缩侧索硬化症（ALS）患者常见的并发症，可能导致死亡。呼吸物理疗法可能改善该人群的肺功能。本研究旨在探讨呼吸物理疗法对 ALS 患者肺功能、咳嗽效果和功能状态的影响。
已在国际前瞻性系统评价注册库（PROSPERO）上发布了方案。研究将涵盖随机对照试验，无语言或出版日期限制，可在以下数据库中获得：MEDLINE/PubMed、EMBASE、Cochrane 图书馆、Web of Science 和物理治疗证据数据库。将使用为每个数据库定制的搜索策略回答研究问题。数据库中的搜索将从 2021 年 1 月至 2022 年 12 月进行。两位作者将分别使用 Cochrane 随机试验风险偏倚工具 V.2 和 Grading of Recommendations, Assessment, Development and Evaluations 评估风险偏倚和证据质量。根据获得的结果，数据将作为荟萃分析或叙述报告报告。
由于本次出版物使用的数据已经发表，因此无需进行先前的伦理批准。本综述的结果将通过同行评议出版物和会议报告披露。
PROSPERO 注册号：CRD42021251842。
