Andreini Daniele, Collet Carlos, Leipsic Jonathon, Nieman Koen, Bittencurt Marcio, De Mey Johan, Buls Nico, Onuma Yoshinobu, Mushtaq Saima, Conte Edoardo, Bartorelli Antonio L, Stefanini Giulio, Sonck Jeroen, Knaapen Paul, Ghoshhajra Brian, Serruys Patrick
Centro Cardiologico Monzino, IRCCS, Milan, Italy; Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Milan, Italy.
Cardiovascular Center Aalst, OLVZ Aalst, Belgium.
J Cardiovasc Comput Tomogr. 2022 Nov-Dec;16(6):558-572. doi: 10.1016/j.jcct.2022.08.003. Epub 2022 Aug 22.
Coronary CT angiography (CCTA) demonstrated high diagnostic accuracy for detecting coronary artery disease (CAD) and a key role in the management of patients with low-to-intermediate pretest likelihood of CAD. However, the clinical information provided by this noninvasive method is still regarded insufficient in patients with diffuse and complex CAD and for planning percutaneous coronary intervention (PCI) and surgical revascularization procedures. On the other hand, technology advancements have recently shown to improve CCTA diagnostic accuracy in patients with diffuse and calcific stenoses. Moreover, stress CT myocardial perfusion imaging (CT-MPI) and fractional flow reserve derived from CCTA (CT-FFR) have been introduced in clinical practice as new tools for evaluating the functional relevance of coronary stenoses, with the possibility to overcome the main CCTA drawback, i.e. anatomical assessment only. The potential value of CCTA to plan and guide interventional procedures lies in the wide range of information it can provide: a) detailed evaluation of plaque extension, volume and composition; b) prediction of procedural success of CTO PCI using scores derived from CCTA; c) identification of coronary lesions requiring additional techniques (e.g., atherectomy and lithotripsy) to improve stent implantation success by assessing calcium score and calcific plaque distribution; d) assessment of CCTA-derived Syntax Score and Syntax Score II, which allows to select the mode of revascularization (PCI or CABG) in patients with complex and multivessel CAD. The aim of this Consensus Document is to review and discuss the available data supporting the role of CCTA, CT-FFR and stress CT-MPI in the preprocedural and possibly intraprocedural planning and guidance of myocardial revascularization interventions.
冠状动脉CT血管造影(CCTA)在检测冠状动脉疾病(CAD)方面显示出较高的诊断准确性,并且在CAD预测试可能性为低至中等的患者管理中发挥着关键作用。然而,对于弥漫性和复杂性CAD患者以及规划经皮冠状动脉介入治疗(PCI)和外科血运重建手术而言,这种非侵入性方法提供的临床信息仍被认为是不足的。另一方面,技术进步最近已显示可提高CCTA对弥漫性和钙化性狭窄患者的诊断准确性。此外,负荷CT心肌灌注成像(CT-MPI)和源自CCTA的血流储备分数(CT-FFR)已作为评估冠状动脉狭窄功能相关性的新工具引入临床实践,有可能克服CCTA的主要缺点,即仅进行解剖学评估。CCTA在规划和指导介入手术方面的潜在价值在于它能提供的广泛信息:a)对斑块扩展、体积和成分的详细评估;b)使用源自CCTA的评分预测CTO PCI的手术成功率;c)通过评估钙化分数和钙化斑块分布来识别需要额外技术(如旋切术和碎石术)以提高支架植入成功率的冠状动脉病变;d)评估源自CCTA的Syntax评分和Syntax评分II,这有助于在复杂多支血管CAD患者中选择血运重建模式(PCI或CABG)。本共识文件的目的是回顾和讨论现有数据,以支持CCTA、CT-FFR和负荷CT-MPI在心肌血运重建干预的术前及可能的术中规划和指导中的作用。