School of Materials and Chemistry, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, China.
The First Clinial Medical College, Nanjing Medical University, No. 101 Longmian Road, Nanjing 211166, China.
Biomolecules. 2022 Aug 7;12(8):1089. doi: 10.3390/biom12081089.
In recent years, multifunctional hydrogels have received a great deal of attention because they are biocompatible and can mimic the extracellular matrix. Herein, we prepared hydrogels of biocompatible cross-linked networks with photothermal properties. In this study, a chitosan/polyaniline/laponite (COL) hydrogel with photothermal conversion capability was designed. Polyaniline was firstly grafted onto chitosan and its solution was mixed with oxidized dextran, which was then cross-linked into a hydrogel via a Schiff base reaction. Furthermore, an aluminosilicate clay material, laponite (LAP), was incorporated into the hydrogel. The swelling ratio of the COL hydrogel in various solutions was greater than 580%, and it showed good degradation ability (the mass-loss ratio was over 45% after 28 days). This composite hydrogel was demonstrated to have good photothermal conversion properties and biocompatibility at both the cell (cell viability was over 97%) and animal levels. The COL hydrogel showed a photothermal conversion efficiency of 23.7% under the irradiation of a near-infrared laser. Coupled with the osteogenic differentiation-inducing potential of LAP, the COL hydrogel has the potential to kill tumors via hyperthermia or serve as scaffolds for bone tissue regeneration.
近年来，多功能水凝胶因其具有生物相容性且能够模拟细胞外基质而受到广泛关注。本文制备了具有光热性能的生物相容性交联网络水凝胶。本研究设计了一种具有光热转换能力的壳聚糖/聚苯胺/膨润土（COL）水凝胶。首先将聚苯胺接枝到壳聚糖上，然后将其溶液与氧化的葡聚糖混合，通过席夫碱反应将其交联成水凝胶。此外，还将一种铝硅酸盐粘土材料膨润土（LAP）掺入到水凝胶中。COL 水凝胶在各种溶液中的溶胀率大于 580%，并且具有良好的降解能力（28 天后质量损失率超过 45%）。该复合水凝胶在细胞（细胞活力超过 97%）和动物水平上均表现出良好的光热转换性能和生物相容性。在近红外激光照射下，COL 水凝胶的光热转换效率为 23.7%。结合 LAP 的成骨分化诱导潜力，COL 水凝胶有望通过高热杀死肿瘤或作为骨组织再生的支架。
