Bang Seongsik, Jee Seungyun, Son Hwangkyu, Cha Hyebin, Park Hosub, Myung Jaekyung, Ko Joo Yeon, Kim Hyunsung, Paik Seungsam
Department of Pathology, Seoul Hospital, Hanyang University College of Medicine, Seoul 04763, Korea.
Department of Dermatology, Seoul Hospital, Hanyang University College of Medicine, Seoul 04763, Korea.
Diagnostics (Basel). 2022 Jul 31;12(8):1859. doi: 10.3390/diagnostics12081859.
CD47 is a cell surface molecule and regulates diverse cellular responses. CD47 is highly expressed in cancer cells and has potential as a therapeutic target and prognostic factor in cancer patients. The expression patterns of CD47 in basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and its precursor lesions, and its clinicopathological significance were investigated. CD47 expression was evaluated by immunohistochemistry in 152 cases of BCC and 71 cases of SCC. For comparison of CD47 expression, actinic keratosis (AK), squamous cell carcinoma in situ (SCCIS), keratoacanthoma (KA), and normal skin (NS) tissue were used. CD47 expression in BCC was significantly lower than that of SCC (p < 0.001). CD47 expression levels in SCC and KA were significantly higher than those of NS and AK (p < 0.05). High CD47 expression was significantly associated with the presence of ulceration (p = 0.005) and a deeper level of invasion (p = 0.011) in BCC. In addition, high CD47 expression was significantly associated with the presence of ulceration (p = 0.019) and larger tumor size (p = 0.004) in SCC. CD47 expression was associated with tumorigenesis and tumor progression in non-melanoma skin cancers.
CD47是一种细胞表面分子，可调节多种细胞反应。CD47在癌细胞中高表达，具有作为癌症患者治疗靶点和预后因素的潜力。研究了CD47在基底细胞癌（BCC）、鳞状细胞癌（SCC）及其前驱病变中的表达模式及其临床病理意义。采用免疫组织化学法对152例BCC和71例SCC进行CD47表达评估。为比较CD47表达情况，使用了光化性角化病（AK）、原位鳞状细胞癌（SCCIS）、角化棘皮瘤（KA）和正常皮肤（NS）组织。BCC中CD47表达显著低于SCC（p<0.001）。SCC和KA中CD47表达水平显著高于NS和AK（p<0.05）。BCC中高CD47表达与溃疡的存在（p=0.005）和更深的浸润深度（p=0.011）显著相关。此外，SCC中高CD47表达与溃疡的存在（p=0.019）和更大的肿瘤大小（p=0.0
