Yu Seong Hyeon, Jung Seung Il
Chonnam National University Medical School, Gwangju 61469, Korea.
Diagnostics (Basel). 2022 Aug 1;12(8):1862. doi: 10.3390/diagnostics12081862.
Historically, urine in the urinary tract was considered "sterile" based primarily on culture-dependent methods of bacterial detection. Rapidly developing sequencing methods and analytical techniques have detected bacterial deoxyribonucleic acid and live bacteria in urine, improving our ability to understand the urinary tract microbiome. Recently, many studies have revealed evidence of a microbial presence in human urine in the absence of clinical infections. In women, fascinating evidence associates urinary tract microbiota with lower urinary tract symptoms (LUTS). However, the association between urinary tract microbiota and men with LUTS, particularly those with benign prostate hyperplasia (BPH), has not been established. In addition, the identification of the proinflammatory cytokines and pathogens responsible for the clinical progression of BPH is still underway. This review article aimed to address microbiome-related evidence for BPH. Further studies are required for a comprehensive understanding of the relationship between the urogenital microbiome and BPH pathogenesis to facilitate the development of preventive and therapeutic approaches for male LUTS.
从历史上看，基于主要依赖培养的细菌检测方法，泌尿道中的尿液被认为是“无菌的”。快速发展的测序方法和分析技术已在尿液中检测到细菌脱氧核糖核酸和活细菌，提高了我们对泌尿道微生物群的理解能力。最近，许多研究揭示了在无临床感染情况下人体尿液中存在微生物的证据。在女性中，有趣的证据将泌尿道微生物群与下尿路症状（LUTS）联系起来。然而，泌尿道微生物群与患有LUTS的男性，尤其是患有良性前列腺增生（BPH）的男性之间的关联尚未确立。此外，导致BPH临床进展的促炎细胞因子和病原体的鉴定仍在进行中。这篇综述文章旨在探讨与BPH相关的微生物群证据。需要进一步研究以全面了解泌尿生殖微生物群与BPH发病机制之间的关系，从而促进男性LUTS预防和治疗方法的发展。
