García-Marqués José Vicente, Talens-Estarelles Cristian, García-Lázaro Santiago, Cerviño Alejandro
Department of Optics and Optometry and Vision Sciences, University of Valencia, C/Dr. Moliner, 50, 46100 Valencia, Spain.
Life (Basel). 2022 Aug 2;12(8):1177. doi: 10.3390/life12081177.
As contact lens (CL) wear affects the ocular surface, this cross-sectional study aims to assess the effects of soft CL wear and its duration on the tear film and meibomian gland (MG) drop-out and visibility. Thirty non-CL wearers (22.5 ± 2.3 years) and twenty-four soft CL wearers (23.8 ± 2.2 years) participated in this study. The Keratograph 5M was used to assess the ocular surface. CL users were surveyed on years of CL wear and hours per week. MG visibility was assessed using a previously developed method based on analysing pixel intensity of meibographies. The CL group showed higher gland drop-out (p < 0.001) and lower gland visibility (p < 0.022). Gland drop-out was independently associated with CL wear (p = 0.006). When gland drop-out was excluded, the relative energy of pixel intensity values showed an independent association with CL wear (p = 0.005). Prolonged hours of CL wear were associated with higher dry eye symptoms and entropy of MGs (p < 0.029). A reduction in non-invasive keratograph break-up time was associated with using CLs for ≥8 years (p = 0.030). Overall, gland drop-out was higher and gland visibility lower in soft CL wearers. New gland visibility metrics might help to assess MGs in soft CL wearers quickly and objectively.
由于佩戴隐形眼镜（CL）会影响眼表，本横断面研究旨在评估软性CL佩戴及其持续时间对泪膜和睑板腺（MG）缺失及可视性的影响。30名非CL佩戴者（22.5±2.3岁）和24名软性CL佩戴者（23.8±2.2岁）参与了本研究。使用角膜地形图仪5M评估眼表。对CL使用者进行了关于CL佩戴年限和每周佩戴小时数的调查。MG可视性采用基于分析睑板腺造影像素强度的先前开发方法进行评估。CL组显示出更高的腺体缺失率（p<0.001）和更低的腺体可视性（p<0.022）。腺体缺失与CL佩戴独立相关（p = 0.006）。当排除腺体缺失因素后，像素强度值的相对能量与CL佩戴呈现独立相关性（p = 0.005）。长时间佩戴CL与更高的干眼症状和MG熵相关（p<0.029）。非侵入性角膜地形图仪测量的泪膜破裂时间缩短与CL佩戴≥8年相关（p = 0.030）。总体而言，软性CL佩戴者的腺体缺失率更高，腺体可视性更低。新的腺体可视性指标可能有助于快速、客观地评估软性CL佩戴者的MG。
