Anumula Lavanya, Ramesh Sindhu, Kolaparthi Venkata Suneel Kumar, Kirubakaran Richard, Karobari Mohmed Isaqali, Arora Suraj, Saleh Ahmed A, Aldowah Omir, Messina Pietro, Scardina Giuseppe Alessandro
Department of Conservative Dentistry and Endodontics, Narayana Dental College and Hospital, Nellore 524003, Andra Pradesh, India.
Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospital, Chennai 600077, Tamil Nadu, India.
Materials (Basel). 2022 Aug 17;15(16):5650. doi: 10.3390/ma15165650.
The role of endogenous Matrix Metallo Proteinases in resin dentin bond deterioration over time has been well documented. The present study aimed to systematically review the literature; in vitro and ex vivo studies that assessed the outcomes of natural cross-linkers for immediate and long-term tensile bond strength were included.
The manuscript search was carried out in six electronic databases-PubMed/MEDLINE, LILACS, SciELO, Cochrane, Web of Science and DOAJ, without publication year limits. Only manuscripts in English (including the translated articles) were selected, and the last search was performed in December 2020. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was followed.
From the 128 potentially eligible studies, 48 full-text articles were assessed for eligibility. After eligibility assessment and exclusions, 14 studies were considered for systematic review and seven studies for meta-analysis. Amongst the selected studies for meta-analysis, three had a medium and four had a low risk of bias.
It was evidenced by the available data that Proanthocyanidin is the most efficient natural cross-linker to date, in preserving the bond strength even after ageing.
内源性基质金属蛋白酶在树脂与牙本质结合强度随时间下降过程中的作用已有充分文献记载。本研究旨在系统回顾文献；纳入了评估天然交联剂对即时和长期拉伸粘结强度影响的体外和离体研究。
在六个电子数据库——PubMed/MEDLINE、LILACS、SciELO、Cochrane、科学引文索引和DOAJ中进行文献检索，无出版年份限制。仅选择英文稿件（包括翻译文章），最后一次检索于2020年12月进行。遵循系统评价和Meta分析的首选报告项目（PRISMA）声明。
从128项潜在符合条件的研究中，评估了48篇全文文章的 eligibility。经过资格评估和排除后，14项研究被纳入系统评价，7项研究被纳入Meta分析。在选定进行Meta分析的研究中，3项风险偏倚为中等，4项风险偏倚为低。
现有数据表明，原花青素是迄今为止最有效的天然交联剂，即使在老化后也能保持粘结强度。
