Fernandes Darren, Andreyev Jervoise
The Department of Gastroenterology, United Lincolnshire NHS Trust, Lincoln County Hospital, Lincoln LN2 5QY, UK.
The Biomedical Research Centre, Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK.
Microorganisms. 2022 Aug 9;10(8):1613. doi: 10.3390/microorganisms10081613.
The human gut microbiome plays a key role in regulating host physiology. In a stable state, both the microbiota and the gut work synergistically. The overall homeostasis of the intestinal flora can be affected by multiple factors, including disease states and the treatments given for those diseases. In this review, we examine the relatively well-characterised abnormalities that develop in the microbiome in idiopathic inflammatory bowel disease, and compare and contrast them to those that are found in radiation enteropathy. We discuss how these changes may exert their effects at a molecular level, and the possible role of manipulating the microbiome through the use of a variety of therapies to reduce the severity of the underlying condition.
人类肠道微生物群落在调节宿主生理方面发挥着关键作用。在稳定状态下，微生物群和肠道协同工作。肠道菌群的整体稳态会受到多种因素的影响，包括疾病状态以及针对这些疾病的治疗方法。在本综述中，我们研究了特发性炎症性肠病中微生物群出现的特征相对明确的异常情况，并将其与放射性肠病中的异常情况进行比较和对比。我们讨论了这些变化如何在分子水平上发挥作用，以及通过使用各种疗法来操纵微生物群以减轻潜在病症严重程度的可能作用。
