CÚRAM, SFI Research Centre For Medical Devices, National University of Ireland Galway, H91 W2TY Galway, Ireland.
Centre for Interdisciplinary Research, D.Y. Patil Education Society, Deemed to be University, Kolhapur 416006, India.
Molecules. 2022 Aug 12;27(16):5154. doi: 10.3390/molecules27165154.
Natural polyphenols have a wide variety of biological activities and are taken into account as healthcare materials. Resveratrol is one such natural polyphenol, belonging to a group known as stilbenoids (STBs). Resveratrol (3,5,4'-trihydroxy--stilbene) is mainly found in grapes, wine, nuts, and berries. A wide range of biological activities has been demonstrated by resveratrol, including antimicrobial, antioxidant, antiviral, antifungal, and antiaging effects, and many more are still under research. However, as with many other plant-based polyphenol products, resveratrol suffers from low bioavailability once administered in vivo due to its susceptibility to rapid enzyme degradation by the body's innate immune system before it can exercise its therapeutic influence. Therefore, it is of the utmost importance to ensure the best use of resveratrol by creating a proper resveratrol delivery system. Nanomedicine and nanodelivery systems utilize nanoscale materials as diagnostic tools or to deliver therapeutic agents in a controlled manner to specifically targeted locations. After a brief introduction about polyphenols, this review overviews the physicochemical characteristics of resveratrol, its beneficial effects, and recent advances on novel nanotechnological approaches for its delivery according to the type of nanocarrier utilized. Furthermore, the article summarizes the different potential applications of resveratrol as, for example, a therapeutic and disease-preventing anticancer and antiviral agent.
天然多酚具有广泛的生物活性，被认为是保健材料。白藜芦醇就是一种天然多酚，属于芪类（STBs）。白藜芦醇（3,5,4'-三羟基- -芪）主要存在于葡萄、葡萄酒、坚果和浆果中。白藜芦醇具有广泛的生物活性，包括抗菌、抗氧化、抗病毒、抗真菌和抗衰老作用，还有更多的作用仍在研究中。然而，与许多其他植物来源的多酚产品一样，由于其容易被体内先天免疫系统中的酶迅速降解，因此在体内给药后，其生物利用度较低，无法发挥治疗作用。因此，通过创建适当的白藜芦醇传递系统来确保白藜芦醇的最佳利用至关重要。纳米医学和纳米递药系统利用纳米级材料作为诊断工具或以受控的方式递送电疗剂，以特定的靶向位置。在简要介绍多酚后，本文综述了白藜芦醇的物理化学特性、有益作用以及根据所使用的纳米载体类型，其传递的最新纳米技术方法进展。此外，本文总结了白藜芦醇的不同潜在应用，例如作为治疗和预防癌症和抗病毒药物的抗癌和抗病毒药物。
