State Key Lab of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing 210023, China.
Health Science Center, Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, China.
Molecules. 2022 Aug 22;27(16):5350. doi: 10.3390/molecules27165350.
Two new guaiane sesquiterpenes, aquisinenoids A and B ( and ), two new eudesmane-type sesquiterpenoids, aquisinenoids C and D ( and ), one new cucurbitacin, aquisinenoid E (), and five known cucurbitacins (-) were isolated from agarwood of . The structures of these new compounds, including their absolute configurations, were characterized by spectroscopic and computational methods. The biological evaluation showed that compounds and had an anti-cancer effect on most of the cancer cells at 5 μM, especially in human breast cancer cells. Interestingly, the new compound exhibited more sensitivity on cancer cells than normal cells, highlighting its potential as a novel anti-cancer agent. Mechanically, compound treatment increased the ROS generation and triggered apoptosis of human breast cancer cells.
从沉香属植物中分离得到两个新的愈创木烷型倍半萜，aquisinenoids A 和 B（和），两个新的桉烷型倍半萜，aquisinenoids C 和 D（和），一个新的葫芦素，aquisinenoid E（），和五个已知的葫芦素（-）。这些新化合物的结构，包括它们的绝对构型，是通过光谱和计算方法来确定的。生物评价表明，化合物和在 5 μM 时对大多数癌细胞具有抗癌作用，特别是对人乳腺癌细胞。有趣的是，新化合物在癌细胞中的敏感性高于正常细胞，这突出了它作为一种新型抗癌药物的潜力。在机制上，化合物处理增加了 ROS 的产生并触发了人乳腺癌细胞的凋亡。
