Ruaro Barbara, Pozzan Riccardo, Confalonieri Paola, Tavano Stefano, Hughes Michael, Matucci Cerinic Marco, Baratella Elisa, Zanatta Elisabetta, Lerda Selene, Geri Pietro, Confalonieri Marco, Salton Francesco
Pulmonology Unit, Department of Medical Surgical and Health Sciences, University Hospital of Cattinara, University of Trieste, 34149 Trieste, Italy.
Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester & Salford Royal NHS Foundation Trust, Manchester M6 8HD, UK.
Pharmaceuticals (Basel). 2022 Aug 22;15(8):1033. doi: 10.3390/ph15081033.
Idiopathic pulmonary fibrosis (IPF) is a rare and severe disease with a median survival of ∼3 years. Several risk factors have been identified, such as age, genetic predisposition, tobacco exposure, and gastro-oesophageal reflux disease (GERD). Prevalence of GERD in IPF is high and may affect 87% of patients, of whom only half (47%) report symptoms. : The aim of this study is to review current evidence regarding the correlation between GERD and IPF and to evaluate the current studies regarding treatments for GERD-IPF. : A review to identify research papers documenting an association between GERD and IPF was performed. : We identified several studies that have confirmed the association between GERD and IPF, with an increased acid exposure, risk of gastric aspiration and bile acids levels in these patients. Few studies focused their attention on GERD treatment, showing how antiacid therapy was not able to change IPF evolution. : This review investigating the correlation between GERD and IPF has confirmed the hypothesized association. However, further large prospective studies are needed to corroborate and elucidate these findings with a focus on preventative and treatment strategies.
特发性肺纤维化（IPF）是一种罕见的严重疾病，中位生存期约为3年。已确定了几个风险因素，如年龄、遗传易感性、烟草暴露和胃食管反流病（GERD）。GERD在IPF中的患病率很高，可能影响87%的患者，其中只有一半（47%）报告有症状。本研究的目的是回顾关于GERD与IPF之间相关性的现有证据，并评估目前关于GERD-IPF治疗的研究。进行了一项综述，以确定记录GERD与IPF之间关联的研究论文。我们确定了几项研究，这些研究证实了GERD与IPF之间的关联，这些患者的酸暴露增加、胃内容物误吸风险和胆汁酸水平升高。很少有研究关注GERD的治疗，表明抗酸治疗无法改变IPF的病程。本综述对GERD与IPF之间的相关性进行了研究，证实了假设的关联。然而，需要进一步的大型前瞻性研究来证实和阐明这些发现，重点是预防和治疗策略。
