Dorantes-Acosta Elisa, Ávila-Montiel Diana, Domínguez Rojas Jesús, Parra-Nigañez Patricia, Velasco-Hidalgo Liliana, Arias Sergio, Gutiérrez-Rivera Lourdes, Juárez-Villegas Luis, Márquez-González Horacio
Biobanco de Investigación en Células Leucémicas, Hospital Infantil de México Federico Gómez, México City, Mexico.
Departamento de Onco-Hematología, Hospital Infantil de México Federico Gómez, México City, Mexico.
Front Pediatr. 2022 Aug 9;10:928612. doi: 10.3389/fped.2022.928612. eCollection 2022.
The new COVID-19 disease is caused by a novel coronavirus (SARS-CoV-2), that probably originated in Wuhan, China, and has currently infected 505,817,953 people and caused 6,213,876 deaths in the world. On the American continent, 152,265,980 cases and 2,717,108 deaths have been reported to WHO (World Health Organization). The Latin America and the Caribbean (LAC) region presents an epidemiological challenge due to its population's heterogeneity and socioeconomic inequality. A particularly vulnerable population is that of children with cancer, and their mortality from COVID-19 has been reported to be 3.6% globally. This work aimed to study the lethality of SARS-CoV-2 infection in children with cancer in the Latin American region. Our objective was to systematically review published scientific literature and search hospital databases in Latin America to explore mortality in this region. A median of mortality of 9.8% was found in the articles analyzed. In addition, we collected five databases from Latin American hospitals. We concluded that there was an underestimation in the mortality registry of this group of patients in the analyzed region. Therefore, although the causes are unknown, it is necessary to strengthen the case-reporting system to determine the reality in complex and particular areas such as Latin America.
新型冠状病毒病（COVID-19）由一种新型冠状病毒（严重急性呼吸综合征冠状病毒2，SARS-CoV-2）引起，该病毒可能起源于中国武汉，目前已在全球感染505,817,953人，造成6,213,876人死亡。在美洲大陆，已向世界卫生组织（WHO）报告了152,265,980例病例和2,717,108例死亡。拉丁美洲和加勒比地区因其人口的异质性和社会经济不平等而面临流行病学挑战。癌症患儿是一个特别脆弱的群体，据报道，他们在全球范围内因COVID-19的死亡率为3.6%。这项研究旨在探讨拉丁美洲地区癌症患儿感染SARS-CoV-2后的致死率。我们的目标是系统回顾已发表的科学文献，并检索拉丁美洲医院的数据库，以探究该地区的死亡率情况。在所分析的文章中，发现死亡率中位数为9.8%。此外，我们还收集了来自拉丁美洲医院的五个数据库。我们得出的结论是，在所分析地区，这组患者的死亡率登记存在低估情况。因此，尽管原因不明，但有必要加强病例报告系统，以确定像拉丁美洲这样复杂且特殊地区的实际情况。
