Wang Menglei, Chen Jiawen, Luo Yawen, Feng Meixin, Yang Qianwen, Tang Yingmei, Tang Ziyi, Xiao Wantong, Zheng Yue, Li Li
Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
Int J Nanomedicine. 2024 Nov 27;19:12719-12742. doi: 10.2147/IJN.S495971. eCollection 2024.
Hydrogels can be rationally designed as multifunctional platforms with structures and functions for various biomedical applications. Because of their excellent biochemical and mechanical properties, hydrogels have shown great potential for promoting angiogenesis, and an increasing amount of research has been devoted to designing and developing new hydrogels. However, a systematic and detailed review of hydrogels that promote angiogenesis is lacking. This paper comprehensively summarizes the design strategies of different kinds of functional hydrogels that promote angiogenesis, with anti-oxidant, substance-delivery, stimulus-responsive, self-healing, conductive, and wound-monitoring properties. The applications of hydrogels in wound healing, bone regeneration, and treatment of myocardial ischemia are discussed. Finally, future development directions of functional hydrogels promoting angiogenesis are proposed along with new strategies for the treatment of related diseases.
水凝胶可以被合理设计成具有多种结构和功能的多功能平台，用于各种生物医学应用。由于其优异的生化和力学性能，水凝胶在促进血管生成方面显示出巨大潜力，并且越来越多的研究致力于设计和开发新型水凝胶。然而，目前缺乏对促进血管生成的水凝胶进行系统而详细的综述。本文全面总结了具有抗氧化、物质递送、刺激响应、自愈合、导电和伤口监测特性的各类促进血管生成的功能性水凝胶的设计策略。讨论了水凝胶在伤口愈合、骨再生和心肌缺血治疗中的应用。最后，提出了促进血管生成的功能性水凝胶的未来发展方向以及治疗相关疾病的新策略。
