State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
J Biomed Mater Res A. 2022 Nov;110(11):1840-1859. doi: 10.1002/jbm.a.37438. Epub 2022 Aug 17.
MXene, as a new two-dimensional nanomaterial, is endowed with lots of particular properties, such as large surface area, excellent conductivity, biocompatibility, biodegradability, hydrophilicity, antibacterial activity, and so on. In the past few years, MXene nanomaterials have become a rising star in biomedical fields including biological imaging, tumor diagnosis, biosensor, and tissue engineering. In this review, we sum up the recent applications of MXene nanomaterials in the field of tissue engineering and regeneration. First, we briefly introduced the synthesis and surface modification engineering of MXene. Then we focused on the application and development of MXene and MXene-based composites in skin, bone, nerve and heart tissue engineering. Uniquely, we also paid attention to some research on MXene with few achievements at present but might become a new trend in tissue engineering and regeneration in the future. Finally, this paper will also discuss several challenges faced by MXene nanomaterials in the clinical application of tissue engineering.
MXene 作为一种新型二维纳米材料，具有许多特殊性质，如大的比表面积、优异的导电性、生物相容性、可生物降解性、亲水性、抗菌活性等。在过去的几年中，MXene 纳米材料已成为生物医学领域的一颗新星，包括生物成像、肿瘤诊断、生物传感器和组织工程。在这篇综述中，我们总结了 MXene 纳米材料在组织工程和再生领域的最新应用。首先，我们简要介绍了 MXene 的合成和表面改性工程。然后，我们重点介绍了 MXene 及其 MXene 基复合材料在皮肤、骨、神经和心脏组织工程中的应用和发展。独特的是，我们还关注了一些目前 MXene 研究成果较少但可能成为组织工程和再生未来新趋势的研究。最后，本文还将讨论 MXene 纳米材料在组织工程临床应用中面临的几个挑战。
