金腰乙素：来自（Silva Manso）Benth. & Hook.f. ex S.Moore 的叶片的一个新的环烯醚萜。
Aureanin: a new iridoid from the leaves of (Silva Manso) Benth. & Hook.f. ex S.Moore.
机构信息
Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt.
Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
出版信息
Nat Prod Res. 2024 Jan-Feb;38(2):236-244. doi: 10.1080/14786419.2022.2114474. Epub 2022 Aug 26.
One new iridoid named aureanin () was isolated from the leaves of (Silva Manso) Benth. & Hook.f. ex S.Moore, together with eight known compounds, isoquercetin (), astragalin (), callicoside B (), amphipaniculoside E (), rehmaglutin D (), quercetin-3-sambubioside (), rutin (), kaempferol-3--rutinoside (). The structures of the isolated compounds were elucidated and confirmed by spectroscopic methods, including 1 D and 2 D NMR experiments, as well as HR-ESI-MS. Compounds were evaluated for their cytotoxic activity against three human cancer cell lines (A549, HepG2, and MCF-7) and . Compound showed activity against A549 (IC: 36.8 ± 1.5 μg/mL, etoposide (positive control): 28.1 ± 4.2 μg/mL), however, none of the compounds were active against .
从（Silva Manso）Benth. & Hook.f. ex S.Moore 的叶子中分离得到一种新的环烯醚萜类化合物 aureanin ()，此外还分离得到了 8 种已知化合物，分别为 isoquercetin ()、astragalin ()、callicoside B ()、amphipaniculoside E ()、rehmaglutin D ()、quercetin-3-sambubioside ()、rutin ()和 kaempferol-3--rutinoside ()。通过光谱方法，包括 1D 和 2D NMR 实验以及 HR-ESI-MS，对分离得到的化合物的结构进行了阐明和确证。评估了化合物对三种人癌细胞系（A549、HepG2 和 MCF-7）和 的细胞毒性活性。化合物 对 A549 具有活性（IC：36.8±1.5μg/mL，阳性对照依托泊苷：28.1±4.2μg/mL），但没有一种化合物对 具有活性。
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