Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Biofouling. 2022 Aug;38(7):687-695. doi: 10.1080/08927014.2022.2116320. Epub 2022 Aug 26.
This study aimed at performing a systematic review of the literature on the effects of epigallocatechin-3-gallate (EGCG) on planktonic cultures and biofilms. The selected references demonstrated that EGCG suppresses acid production by inhibiting the activity of enzymes such as lactate dehydrogenase and FIF0-ATPase. Regarding virulence factors, one study reported a reduction in soluble and insoluble polysaccharide synthesis, another demonstrated that EGCG inhibited GTase activity, and another showed effects of EGCG on the expression of B, C, and D. The effects of EGCG on biofilms were reported only by 2 of the selected studies. Moreover, high variability in effective concentrations and microbial assessment methods were observed. The literature suggests that EGCG has effects against planktonic cells viability and virulence factors. However, the literature lacks studies with appropriate biofilm models to evaluate the precise effectiveness of EGCG against biofilms.
本研究旨在对表没食子儿茶素没食子酸酯（EGCG）对浮游培养物和生物膜影响的文献进行系统综述。所选参考文献表明，EGCG 通过抑制乳酸脱氢酶和 FIF0-ATP 酶等酶的活性来抑制酸的产生。关于毒力因子，一项研究报告称可溶性和不溶性多糖合成减少，另一项研究表明 EGCG 抑制 GTase 活性，另一项研究表明 EGCG 对 B、C 和 D 的表达有影响。只有 2 项选定的研究报告了 EGCG 对生物膜的影响。此外，还观察到有效浓度和微生物评估方法的高度可变性。文献表明，EGCG 对浮游细胞活力和毒力因子有影响。然而，文献中缺乏使用适当的生物膜模型来评估 EGCG 对生物膜的确切有效性的研究。
