The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, China.
Shanghai Xuhui Central Hospital, Shanghai, China.
Clinics (Sao Paulo). 2022 Aug 23;77:100095. doi: 10.1016/j.clinsp.2022.100095. eCollection 2022.
Depression is common after both lacunar stroke and non-lacunar stroke and might be associated with lesion locations as proven by some studies. This study aimed to identify whether lesion location was critical for depression after both lacunar and non-lacunar strokes.
A cohort of ischemic stroke patients was assigned to either a lacunar stroke group or a non-lacunar stroke group after a brain MRI scan. Neurological deficits and treatment response was evaluated during hospitalization. The occurrence of depression was evaluated 3 months later. Logistic regressions were used to identify the independent risk factors for depression after lacunar and non-lacunar stroke respectively.
83 of 246 patients with lacunar stroke and 71 of 185 patients with non-lacunar stroke developed depression. Infarctions in the frontal cortex, severe neurological deficits, and a high degree of handicap were identified as the independent risk factors for depression after non-lacunar stroke, while lesion location was not associated with depression after lacunar stroke.
The main determinants for depression after lacunar and non-lacunar stroke were different. Lesion location was critical only for depression after non-lacunar stroke.
腔隙性卒中和非腔隙性卒中后均常见抑郁，且一些研究表明抑郁可能与病灶部位相关。本研究旨在确定腔隙性卒中和非腔隙性卒中后抑郁是否与病灶部位有关。
对脑 MRI 扫描后的缺血性卒中患者进行分组，分为腔隙性卒中组或非腔隙性卒中组。在住院期间评估神经功能缺损和治疗反应。3 个月后评估抑郁的发生。使用逻辑回归分别确定腔隙性卒中和非腔隙性卒中后抑郁的独立危险因素。
246 例腔隙性卒中患者中有 83 例和 185 例非腔隙性卒中患者中有 71 例发生抑郁。额叶皮质梗死、严重神经功能缺损和高度残疾被确定为非腔隙性卒中后抑郁的独立危险因素，而腔隙性卒中后抑郁与病灶部位无关。
腔隙性卒中和非腔隙性卒中后抑郁的主要决定因素不同。病灶部位仅与非腔隙性卒中后抑郁有关。
