Kaluarachchi T D Jayasena, Campbell Paul M, Wickremasinghe Renu, Ranasinghe Shalindra, Yasewardene Surangi, De Silva Hiromel, McBain Andrew J, Weerasekera Manjula
Department of Parasitology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.
Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Trop Med Health. 2022 Aug 26;50(1):58. doi: 10.1186/s41182-022-00455-y.
Cutaneous leishmaniasis (CL) lesions are chronic and result in disfiguring scars. The microbiological aspects of these wounds have not been systematically investigated. We have recently reported that 61.5% of CL wounds in a Sri Lankan cohort harboured bacterial biofilms, mainly composed of bacilli, Enterobacteriaceae, and Pseudomonas, which could delay wound healing. We have additionally reported that biofilms were significantly associated patients over 40 years of age, discharge, pain and/or itching of the wound, and high pus cell counts. Using this as background knowledge and other relevant literature, we highlight the importance of investigating the role of biofilms in CL wound healing, clinical indicators, cost-effective laboratory tests involving less invasive sampling techniques for diagnosing biofilms and potential therapeutic options for biofilm-containing CL wounds, such as adjunctive application of wound debridement and antimicrobial treatment along with anti-parasitic drugs.
皮肤利什曼病（CL）病变是慢性的，会导致毁容性疤痕。这些伤口的微生物学方面尚未得到系统研究。我们最近报告称，在一个斯里兰卡队列中，61.5%的CL伤口含有细菌生物膜，主要由杆菌、肠杆菌科细菌和假单胞菌组成，这可能会延迟伤口愈合。我们还报告称，生物膜与40岁以上的患者、伤口渗液、疼痛和/或瘙痒以及高脓细胞计数显著相关。基于这些背景知识和其他相关文献，我们强调了研究生物膜在CL伤口愈合中的作用、临床指标、涉及侵入性较小的采样技术的经济高效的实验室检测方法以诊断生物膜，以及针对含生物膜的CL伤口的潜在治疗选择的重要性，例如联合应用伤口清创术和抗菌治疗以及抗寄生虫药物。
