Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Adv Exp Med Biol. 2022;1382:109-118. doi: 10.1007/978-3-031-05460-0_8.
Mitochondrial function is essential to ensure vital cellular processes. Given the energy requirement of the brain, neuronal function, viability, and survival are closely related to proper mitochondrial function. Dysregulation of mitochondrial processes can lead to several detrimental effects in the cells and stablish the condition of mitochondrial dysfunction. This dysfunction is proposed to be greatly implicated in several neurodegenerative diseases, with evidence of compromised mitochondrial function and dynamics in Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.
线粒体功能对于确保细胞的基本生命过程至关重要。由于大脑对能量的高需求，神经元的功能、活力和存活与适当的线粒体功能密切相关。线粒体过程的失调会导致细胞产生多种有害影响，并导致线粒体功能障碍。这种功能障碍被认为与几种神经退行性疾病密切相关，有证据表明在阿尔茨海默病、帕金森病、亨廷顿病和肌萎缩侧索硬化症中，线粒体功能和动力学受损。
