Jiangsu Agri-animal Husbandry Vocational College, Taizhou, Jiangsu 225300, PR China.
Jiangsu Agri-animal Husbandry Vocational College, Taizhou, Jiangsu 225300, PR China.
Biomed Pharmacother. 2022 Oct;154:113561. doi: 10.1016/j.biopha.2022.113561. Epub 2022 Aug 24.
In recent years, increasing attention has been paid to the pharmacological efficacy of tannins. Tannic acid (TA), the simplest hydrolysable tannin that has been approved by the FDA as a safe food additive, is one of the most important components of these traditional medicines. Studies have shown that TA displays a wide range of pharmacological activities, such as anti-inflammatory, neuroprotective, antitumor, cardioprotective, and anti-pathogenic effects. Here, we summarize the known pharmacological effects and associated mechanisms of TA. We focus on the effect and mechanism of TA in various animal models of inflammatory disease and organ, brain, and cardiovascular injury. Moreover, we discuss the possible molecular targets and signaling pathways of TA, in addition to the pharmacological effects of TA-based nanoparticles and TA in combination with chemotherapeutic drugs.
近年来，人们越来越关注单宁的药理功效。鞣酸（TA）是 FDA 批准的安全食品添加剂，也是这些传统药物中最重要的成分之一，它是最简单的可水解单宁。研究表明，TA 具有广泛的药理活性，如抗炎、神经保护、抗肿瘤、心脏保护和抗病原体作用。在这里，我们总结了 TA 的已知药理作用及其相关机制。我们重点介绍了 TA 在各种炎症性疾病和器官、大脑和心血管损伤的动物模型中的作用和机制。此外，我们还讨论了 TA 的可能分子靶点和信号通路，以及基于 TA 的纳米粒子和 TA 与化疗药物联合使用的药理作用。
