Department of Orthopedic Surgery, Linping Campus, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 31000, Zhejiang, China.
Department of Dermatology and Venereology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310000, Zhejiang, China.
Sci Rep. 2022 Aug 27;12(1):14653. doi: 10.1038/s41598-022-19135-2.
Patients with cutaneous psoriasis (PsC) and psoriatic arthritis (PsA) are reported with increased cancer risk, but the underlying mechanism is less clear, especially the association between the presence of PsA and cancer risk. Motivated by the role of ferroptosis in the progression of cancers as well as inflammation response in psoriasis, this experiment attempts to investigate the relationship between ferroptosis regulators and hub genes in PsA by bioinformatic analysis. The findings revealed an exclusive correlation between CISD1 (ferroptosis regulator) and CLEC2B (hub gene) in PsA group as well as multiple cancer types. Furthermore, CLEC2B was discovered differentially expressed in a variety of cancers and is closely associated with immune cell infiltration as well as immune checkpoints. These results indicate that ferroptosis may act as a bridge between psoriatic arthritis and the onset of certain malignancies.
患有皮肤银屑病（PsC）和银屑病关节炎（PsA）的患者报告有更高的癌症风险，但潜在机制尚不清楚，特别是 PsA 与癌症风险之间的关系。受铁死亡在癌症进展以及银屑病炎症反应中的作用的启发，本实验试图通过生物信息学分析研究铁死亡调节剂与 PsA 中枢纽基因之间的关系。研究结果表明，CISD1（铁死亡调节剂）和 CLEC2B（枢纽基因）在 PsA 组以及多种癌症类型之间存在独特的相关性。此外，CLEC2B 在多种癌症中表达差异，与免疫细胞浸润和免疫检查点密切相关。这些结果表明，铁死亡可能是银屑病关节炎和某些恶性肿瘤发病之间的桥梁。
