SIVmac239 在人源化小鼠中连续传代后的进化。
Evolution of SIVmac239 following serial passaging in humanized mice.
机构信息
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
ADEAR Training Program, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
出版信息
J Med Primatol. 2022 Oct;51(5):284-287. doi: 10.1111/jmp.12614. Epub 2022 Aug 28.
Serial passage of SIVmac239 allows for greater understanding of the genetic changes necessary for cross-species transmission of primate lentiviruses into humans. Using humanized mice, we show that adaptive mutations continue to accumulate in SIVmac239 during four serial passages, with persistent CD4 T cell decline and increases in plasma viral loads.
连续传代 SIVmac239 有助于更好地了解灵长类慢病毒跨越物种传播到人身上所需的遗传变化。我们用人源化小鼠表明，在连续传代 4 次的过程中，SIVmac239 中持续积累适应性突变，CD4 T 细胞持续下降，血浆病毒载量增加。
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