SIVcpz 跨物种传播及在人源化小鼠模型中向 HIV-1 的病毒进化。
SIVcpz cross-species transmission and viral evolution toward HIV-1 in a humanized mouse model.
机构信息
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
出版信息
J Med Primatol. 2020 Feb;49(1):40-43. doi: 10.1111/jmp.12440. Epub 2019 Oct 1.
Abstract
HIV-1 evolved from its progenitor SIV strains, but details are lacking on its adaptation to the human host. We followed the evolution of SIVcpz in humanized mice to mimic cross-species transmission. Increasing viral loads, CD4 T-cell decline, and non-synonymous mutations were seen in the entire genome reflecting viral adaptation.
摘要
HIV-1 是从其前体 SIV 株进化而来的，但它适应人类宿主的细节尚不清楚。我们通过在人源化小鼠中跟踪 SIVcpz 的进化来模拟跨物种传播。整个基因组中观察到病毒载量增加、CD4 T 细胞减少和非同义突变，反映了病毒的适应性。
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