Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
ADEAR Training Program, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
J Med Primatol. 2023 Oct;52(5):294-297. doi: 10.1111/jmp.12675. Epub 2023 Sep 1.
HIV-1 emerged from SIVcpz evolving in humans. Humanized mice are an effective tool for assessing viral evolution via measuring viral loads, CD4 T cell decline, and analyzing genetic changes. Four serial passages showed many non-synonymous mutations important for the adaptation and evolution of SIVcpz to human immune cells.
HIV-1 源自于在人类中进化的 SIVcpz。人源化小鼠是评估病毒进化的有效工具，可通过测量病毒载量、CD4 T 细胞下降和分析遗传变化来实现。四次连续传代显示了许多非同义突变，这些突变对于 SIVcpz 适应和进化为人免疫细胞是重要的。
