Schmitt Kimberly, Curlin James, Remling-Mulder Leila, Moriarty Ryan, Goff Kelly, O'Connor Shelby, Stenglein Mark, Marx Preston, Akkina Ramesh
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
J Med Primatol. 2020 Oct;49(5):284-287. doi: 10.1111/jmp.12485. Epub 2020 Aug 17.
HIV-1 evolved from SIV during cross-species transmission events, though viral genetic changes are not well understood. Here, we studied the evolution of SIVcpzLB715 into HIV-1 Group M using humanized mice. High viral loads, rapid CD4 T-cell decline, and non-synonymous substitutions were identified throughout the viral genome suggesting viral adaptation.
HIV-1在跨物种传播事件中从SIV进化而来,尽管病毒的基因变化尚不清楚。在此,我们利用人源化小鼠研究了SIVcpzLB715向HIV-1 M组的进化。在整个病毒基因组中发现了高病毒载量、CD4 T细胞快速减少和非同义替换,提示病毒适应。