Fisica Sanitaria, Azienda Ospedaliero Universitaria Pisa AOUP, ed.18 via Roma 67, Pisa, Italy; Centro Pisano ricerca e implementazione clinica Flash Radiotherapy (CPFR@CISUP), Presidio S. Chiara, ed. 18 via Roma 67, Pisa, Italy; INFN, Sezione di Pisa, Largo B. Pontecorvo 3, I-57127 Pisa, Italy.
Centro Pisano ricerca e implementazione clinica Flash Radiotherapy (CPFR@CISUP), Presidio S. Chiara, ed. 18 via Roma 67, Pisa, Italy.
Phys Med. 2022 Oct;102:9-18. doi: 10.1016/j.ejmp.2022.08.010. Epub 2022 Aug 27.
Ultra-High dose-per-pulse regimens (UHDP), necessary to trigger the "FLASH" effect, still pose serious challenges to dosimetry. Dosimetry plays a crucial role, both to significantly improve the accuracy of the radiobiological experiments necessary to fully understand the mechanisms underlying the effect and its dependencies on the beam parameters, and to be able to translate such effect into clinical practice. The standard ionization chamber in UHDP region is significantly affected by the effects of the electric field generated by the enormous density of charges produced by the dose pulse. This work describes the theory and the conceptual design of a gas chamber (the ALLS chamber) which overcomes the above-mentioned problems.
超高剂量脉冲方案（UHDP）对于触发“FLASH”效应是必要的，但仍然对剂量测量带来了严峻的挑战。剂量测量在提高必要的放射生物学实验的准确性方面起着至关重要的作用，这些实验有助于充分理解效应的机制及其对射束参数的依赖性，同时也有助于将这种效应转化为临床实践。在 UHDP 区域，标准电离室受到由剂量脉冲产生的巨大电荷密度产生的电场的影响。本工作描述了一种气体室（ALLS 室）的理论和概念设计，该气体室克服了上述问题。
